Isolation of DNA polymerase gamma from an adenovirus 2 DNA replication complex
نویسندگان
چکیده
منابع مشابه
Isolation of DNA Polymerase y from an Adenovirus 2 DNA Replication Complex
Several recent studies have provided considerable new information on the replication of the linear adenovirus DNA genome (4, 8, 1317). However, the exact mechanism of adenovirus DNA replication and the enzymes involved remain largely obscure. Recently we have described the properties of a nuclear membrane fraction isolated from adenovirus 2infected KB cells that has some properties of a functio...
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Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents. On the other hand, adenoviruses are notorious pathogens in people with compromised immune functions. This article will briefly summarize the basi...
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The in vitro adenovirus (Ad) DNA replication system provides an assay to study the interaction of viral and host replication proteins with the DNA template in the formation of the preinitiation complex. This initiation system requires in addition to the origin DNA sequences 1) Ad DNA polymerase (Pol), 2) Ad preterminal protein (pTP), the covalent acceptor for protein-primed DNA replication, and...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1975
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.15.6.1507-1510.1975